Body of Abstract: Cell potency describes the developmental potential of cells. Stem cells are pluripotent and can specify many different lineages, whereas differentiated cells stop dividing or divide to give rise only to the same type of cell. Previous studies comparing chromatin states between these two cell types found that stem cells have a state of hyperdynamic chromatin, defined by loosely-bound chromatin proteins that hypothetically allows for more developmental plasticity in stem cells versus differentiated cells. Parallel to this, comparisons between stem cells of the shoot apical meristem and differentiated leaf mesophyll cells in Arabidopsis thaliana revealed vastly increased accessibility in the stem cell chromatin. Further, mesophyll accessible sites tended to also be accessible in the stem cells, but not vice versa. This further alludes to a potentially direct relationship between hyperdynamic chromatin and developmental plasticity. To test this experimentally, we have modified a technique previously used in Drosophila S2 cells for measuring nucleosome turnover for use in specific cell types of Arabidopsis. This approach will be applied to measure nucleosome dynamics in wild-type and mutant stem and differentiated cells. We expect this work to shed light on the differences in chromatin dynamics between cell types and how these relate to cell potency.