Body of Abstract: Wounding of plant tissues triggers series of stress protective regulations such as enhanced biosynthesis of secondary metabolites and upregulation of antioxidant enzyme responses. Accumulation of suberin polyphenolics (SPP) is an integral part of wound healing (WH) responses of potato tubers and potentially related to the biosynthesis of phenolic metabolites. Antioxidant enzymes also play critical role in stress modulation during WH of plants. The main objective of this study was to elucidate the role of phenolic metabolites and antioxidant enzyme responses during WH of potato tubers. A disc model system was employed to study the WH responses of fifteen potato cultivars with varying WH characteristics. Two biological elicitors (chitosan oligosaccharide-COS and bioprocessed cranberry pomace-NutriCran) alone or in combination were used to accelerate WH responses of potato tubers. Accumulation of SPP during closing layer formation was determined histologically. Phenolic content, phenolic profile, proline content, and activity of glucose-6-phosphate dehydrogenase (G6PDH), succinate dehydrogenase (SDH), proline dehydrogenase (PDH), and antioxidant enzymes of select potato cultivars were determined after 0, 3, 6, and 9 d of WH. Elicitor treatments, especially COS+NutriCran accelerated WH responses with improved accumulation of SPP in most potato cultivars after 3-6 d of wounding. Increased concentration of phenolic metabolites (e.g., chlorogenic acid, ferulic acid, gallic acid, and catechin) was found in rapidly healed tissues after 3 and 6 d of wounding. Higher activity of G6PDH, PDH, and guaiacol peroxidase (GPX) also detected in elicitor treated tissues during WH. Results of this study indicate that biosynthesis of phenolic metabolites and enhanced activity of GPX are critical part of wound-induced stress modulation of potato tuber tissues. Biological elicitors can be utilized to accelerate WH responses in potato tubers for mitigating wounding-associated postharvest losses.