Body of Abstract: One of the major challenges that affects food production and threatens food security is soil salinization, which affects 10% of cultivated lands. Over recent years, our team has identified wild tomato accessions (Solanum pimpinellifolium and Solanum cheesmaniae, originating from South America and the Galapagos Islands respectively), that were able to maintain their biomass and/or yield in saline conditions as compared to control conditions. Robust and salt-tolerant F1 hybrid rootstocks were generated by crossing tomato cultivars (Solanum lycopersicum) with wild tomato accessions of the fore-mentioned species. Commercial tomato cultivars with excellent fruit characteristics were then grafted onto these F1 hybrid rootstocks and evaluated for yield performance in control (0 mM NaCl) and saline (7% seawater) conditions. The results demonstrate that some of the interspecific F1 hybrids when used as rootstocks enabled increased yield production under salt stress when compared to the parental lines and self-grafted plants. These newly generated F1 hybrid rootstocks performed comparably to the widely used commercial rootstocks.