Body of Abstract: Synthetic apomixis in wheat is one method to create self-reproducing wheat hybrids. By definition, self-reproducing hybrid plants produce offspring identical to the parent and maintain hybrid vigor over multiple generations. Creating synthetic apomixis in wheat involves two components: replacing meiosis in the egg cell with mitosis (“meiosis instead of mitosis” or MiMe) and development of an embryo from an unfertilized egg cell, or parthenogenesis. To avoid meiosis, knock-out mutations in 3 genes must be combined to yield non-recombined, non-reduced clonal gametes. Parthenogenesis can be achieved by inducing embryo formation of the unfertilized egg cell. We have successfully demonstrated parthenogenesis in wheat using an egg cell-specific promoter to express Babyboom (BBM) orthologous genes. The generation of 1c plants from the parthenogenic embryos was confirmed by flow cytometry. Mutations with knockout or knockdown alleles of MiMe loci may be combined with BBM parthenogenesis components to achieve an apomictic plant, e.g. a flowering plant, in the absence of egg cell fertilization, comprising clonal gametes and progeny.