Body of Abstract: The present study analyzes the potential role of H2S and bacteria in mitigating the toxicity of Cd in rice plants, although, very little work has been done on this aspect. To this end, our findings are novel revealing the beneficial influence of interrelation among H2S and bacteria in plant tolerance against Cd toxicity. We bifurcated our work as follows; (i) isolation, screening, and characterization of Cd and H2S tolerant bacteria, (iii) analyzing the abilities of tolerant bacteria and H2S to alleviate the impact of Cd toxicity on rice plant growth. Primarily, 11 bacterial isolates were screened relying on Cd and H2S tolerance at different concentrations, the outcome revealed that two bacterial isolates S6D1-105, and S2D2-111 were tolerant to Cd and H2S at their max. concentration. Moreover, the minimum inhibitory concentration (MIC) of Cd was determined, and isolate S2D2-111 manifested max. resistance at 1800 μM CdCl2 concentration. To access PGPR traits of bacteria, and different mineral solubilization assays, the selected bacterial isolate S2D2-111 was capable to solubilize phosphate and potassium and showed enhanced production of siderophore, protease, and ammonia. Additionally, S2D2-111 was identified through 16S rRNA gene sequencing analysis which identified the selected isolate as Bacillus thuringiensis. Furthermore, the growth of three rice varieties was reduced under Cd stress. Rice plants exhibited enhanced growth under the combined treatments of H2S and bacteria relative to Cd stress alone accompanying, MDA, H2O2, H2S, soluble protein, chlorophyll contents, non-enzymatic and enzymatic antioxidants activities were also improved under consortium of H2S+Cd+Bac. Meanwhile, the stomatal density of leaf, SEM, and ion balance revealed improvement by the co-application of H2S and Bacillus thuringiensis in rice plants grown under Cd stress. Thus, H2S and bacteria could be effective bio-source for enhancing tolerance in rice plants in response to Cd toxicity.