Body of Abstract: Long duration spaceflights and habitation of the Moon and Mars will require plants as vital components in regenerative life support systems. Each of these environments presents a unique intensity in gravity. Understanding how plants respond to micro and fractional gravity levels will better prepare us to develop plants that can thrive in space. Multiple RNAseq datasets have been produced to assess responses to fractional gravity levels. Both centrifuges on the ISS and ground-based simulations have been used to quantify the transcriptomes of plants exposed to varying intensities of gravity. A meta-analysis of three spaceflight datasets and one ground experiment has allowed us to look across 13 gravity levels to find trends in differential expression. Several core patterns emerged. Although plants show a gravity responsive phenotype at both Lunar and Martian gravity, there were consistently higher levels of differential expression between microgravity to Lunar or Martian gravity than between microgravity and Earth gravity. Additionally, a consistent trend appeared between the spaceflight and ground datasets. While the ground study did use multiple methods to simulate fractional gravity, the transcriptomes from these plants consistently showed less similarity to the spaceflight analogs than separate flights showed to each other. Interestingly, while all spaceflight datasets were exposed to a consistent radiation environment, fractional gravity levels showed differential expression of reactive oxygen species (ROS) related genes. These findings highlight the multiplying nature of plant stresses, where each additional stress amplifies the response of seemingly unrelated stress mechanisms. Taken together, this analysis has highlighted key genes consistently used in plant responses at multiple key gravity levels. These findings also emphasize the unique nature of the spaceflight environment. While individual features of spaceflight can be simulated on Earth, the combination of these features produces growth conditions that can only truly be studied in space.