Climate change is an existential threat to global food production and food security. Modelers calculate that, since 1971, climate change resulting from human activity has slowed growth in agricultural productivity by about a fifth. Rising temperatures and changing precipitation patterns are already shifting areas where different crops can be grown. And climate change is expected to get worse. It is predicted that temperatures will rise by 1-2 Celsius (C) from the preindustrial age, and for every 1-degree C increase, the global yields of the world’s three major cereals—rice, wheat and maize—are predicted to decrease by roughly 3, 6 and 7 percent, respectively. The challenge will be to help agriculture meet the food demands of an expanding world population while decreasing its contribution to global greenhouse gas emissions. Research is essential in meeting these challenges. Innovations in technologies and practices developed from research have been the primary driver of agricultural productivity. Furthermore, growth in productivity, also known as Total Factor Productivity, has reduced net global land conversion to cropland and, consequently, reduced GHG emissions. In this presentation, I will explore opportunities to bring advances in biology, genomics, big data and analytics, to create game-changing innovations that would sustain and even increase agricultural productivity in a changing climate and reduce GHG emissions. I will also discuss the fundamental changes that need to happen in the way we do research to ensure that innovations from research reach the intended impact.